Preliminary Study on the Safety of Brucella Vaccine S2 Strain on
Goats Immunized via Vagina
Brucellosis is a kind of zoonosis caused by Brucella,which seriously endangers human and animal health,and is mainly controlled through vaccination in areas where animal brucellosis is prevalent. After practices for several years,a new immune technology(immunization via vagina)was developed in Jianchang County of Liaoning Province,and good immune effects have been achieved. In order to make clear the safety of the technology on animals,3 goats were vaccinated,one month later,their antibody titer and bacterial content were detected and the pathological changes of their spleens and livers were observed. The results showed that the antibodies in the three goats turned to be positive,no Brucella was isolated from all the organs collected,and no pathological changes related to brucellosis were found in spleens and livers. These results preliminarily indicated that it was safe to immunize goat with Brucella vaccine S2 strain via the vagina.