為檢驗泰萬菌素對豬繁殖與呼吸綜合征（PRRS）的防控效果，用2種泰萬菌素制品（A、B）和黃芪多糖飼喂妊娠母豬，通過統(tǒng)計臨床生產(chǎn)指標、母豬和仔豬抗體水平、病毒檢出率以及細胞因子IL-2、IFN-γ表達水平等，綜合評價泰萬菌素的PRRS防控效果。結(jié)果顯示：泰萬菌素的PRRS防控效果明顯優(yōu)于黃芪多糖，其中泰萬菌素A、B組母豬的產(chǎn)健仔率由試驗前的84.98%分別提高到94.44%、91.89%，產(chǎn)弱胎、死胎或木乃伊胎率相應降低；泰萬菌素A、B組母豬流產(chǎn)率降低，體內(nèi)抗體下降速率減緩，所產(chǎn)仔豬抗體穩(wěn)定性和整齊度提高，母豬血液中的PRRS病原檢出率和濃度降低，IL-2表達水平下降，IFN-γ表達水平上升。結(jié)果表明，泰萬菌素可降低妊娠母豬因PRRS造成的繁殖障礙率，同時可通過調(diào)控細胞因子水平增強機體免疫力，從而起到防控PRRS的作用。本研究為PRRS防控提供了一種新思路。
Evaluation of Prevention and Control Effect of Tylvalosin on PRRS
In order to evaluate the prevention and control effect of tylvalosin on porcine reproductive and respiratory syndrome（PRRS），pregnant sows were fed with two kinds of tylvalosin products（A and B）and astragalus polysaccharide to comprehensively evaluate the effect of tylvalosin by means of clinical production indicators，antibody levels in sows and piglets，virus detection rate and expression level of cytokines IL-2 and IFN-γ. The results showed that，compared to astragalus polysaccharide，tylvalosin was more effective for PRRS，for groups tylvalosin A and B，the healthy litter rates of sows were increased from 84.98%（prior to evaluation）to 94.44% and 91.89%，respectively，and the rates of weak fetus，stillbirth or mummified fetus decreased accordingly；the abortion rate decreased，the decline rate of antibody level in vivo slowed down，the stability and uniformity of antibody level in their piglets increased，the detection rate and concentration of PRRS pathogens in sows' blood decreased，the expression level of IL-2 decreased，and that of IFN-γ increased. In conclusion，tylvalosin could reduce the reproductive disorder caused by PRRS in pregnant sows，enhance immunity by regulating the level of cytokines，and consequently prevent and control PRRS. A new idea was thereby provided by the study for PRRS prevention and control.
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